Intramolecular Benzyne-Phenolate [4+2] Cycloadditions.
Hiroshi TakikawaArata NishiiHiromu TakiguchiHirotoshi YagishitaMasato TanakaKeiichi HiranoMasanobu UchiyamaKen OhmoriKeisuke SuzukiPublished in: Angewandte Chemie (International ed. in English) (2020)
An intramolecular benzyne-phenolate [4+2] cycloaddition is reported. Benzyne precursors, having vicinal halogen-sulfonate functionalities, linked with a phenol(ate) by various tether groups undergo efficient intramolecular [4+2] cycloaddition by treatment with either Ph3 MgLi or nBuLi for halogen-metal exchange to form various benzobarrelenes.