Reduced fibroblast growth factor 21 and β-Klotho secretion in untreated congenital isolated GH deficiency.
Alécia A Oliveira-SantosRoberto SalvatoriAna C BuenoMonica C NogueiraViviane C CamposManuela A MeloCarla R P OliveiraCynthia S Barros-OliveiraCindi G MarinhoNayra P DamascenaElenilde G SantosEnaldo V MeloFrancisco J A de PaulaMargaret de CastroManuel H Aguiar-OliveiraPublished in: Endocrine (2021)
Subjects with lifetime, untreated IGHD exhibit reduced FGF21 and β-Klotho levels response to a mixed meal. This difference may have consequences on metabolism and aging.
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