D-alanine inhibits murine intestinal inflammation by suppressing IL-12 and IL-23 production in macrophages.

Hikaru HashimotoTomohisa TakagiKohei AsaedaTakeshi YasudaMariko KajiwaraTakeshi SugayaKatsura MizushimaKen InoueKazuhiko UchiyamaKazuhiro KamadaYasuki HigashimuraRyo Inoue Yuji NaitoYoshito Itoh

Published in: Journal of Crohn's & colitis (2024)

Our results suggest that D-alanine prevents dextran sulfate sodium-induced colitis in mice and suppresses IL-12p35 and IL-23p19 production in macrophages.

Keyphrases

oxidative stress
type diabetes
signaling pathway
metabolic syndrome
skeletal muscle
adipose tissue