Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.

Xi ChenChengsong XieWotu TianLixin SunWang ZhengSarah HawesLisa ChangJustin KungJinhui DingShengdi ChenWeidong LeHuai-Bin Cai

Published in: Molecular neurodegeneration (2020)

Our findings support an important physiological function of LRRK2 in maintaining nuclear structure integrity and genomic stability during the normal aging process, suggesting that PD-related LRRK2 mutations may cause the deterioration of neuronal structures through accelerating the aging process.

Keyphrases

copy number
spinal cord
spinal cord injury
functional connectivity
computed tomography
tyrosine kinase
protein kinase
brain injury
drug induced
subarachnoid hemorrhage
cone beam