Toxicities and Response Rates of Secondary CNS Lymphoma After Adoptive Immunotherapy With CD19-Directed Chimeric Antigen Receptor T Cells.

Philipp KarschniaKai RejeskiMichael WinkelmannFlorian SchöberlVeit L BückleinViktoria BlumenbergChristian SchmidtJens BlobnerMichael von Bergwelt-BaildonJoerg-Christian TonnWolfgang G KunzMarion SubkleweLouisa von Baumgarten

Published in: Neurology (2022)

CAR T cells induce considerable antitumor effects in SCNSL, and CNS response reflects systemic response. Neurotoxicity appears similar to previous reports on patients with lymphoma without CNS involvement. CAR T cells may therefore represent an effective and safe therapy for SCNSL.

Keyphrases

blood brain barrier
diffuse large b cell lymphoma
emergency department
stem cells
cell therapy
electronic health record