Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells: studies on the mechanisms of action.

Lavinia CasatiFrancesca PaganiPatrizia LimontaClaudia VanettiGiovanni StancariValeria Sibilia

Published in: European journal of nutrition (2019)

The δ-TT protective effect against oxidative damage in MC3T3-E1 cells is due to a reduction of intracellular ROS levels and an increase of the GSH/GSSG ratio, and involves an interaction between the PI3K/Akt-Nrf2 signaling pathways.

Keyphrases

induced apoptosis
oxidative stress
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
dna damage
cell death
reactive oxygen species
epithelial mesenchymal transition
cell proliferation
case control
heat stress