Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.
Dongwon ChoiEunkyung ParkRoy P YuMichael N CooperIl-Taeg ChoJoshua ChoiJames YuLuping ZhaoJi-Eun Irene YumJin Suh YuBrandon NakashimaSunju LeeYoung Jin SeongWan JiaoChester J KohPeter BalukDonald M McDonaldSindhu SaraswathyJong Yeon LeeNoo Li JeonZhenqian ZhangAlex S HuangBin ZhouAlex K WongYoung-Kwon HongPublished in: Circulation research (2022)
Piezo1 is an upstream mechanosensor for the lymphatic mechanotransduction pathway and regulates lymphatic growth in response to external physical stimuli. Piezo1 activation presents a novel therapeutic opportunity for preventing postsurgical lymphedema. The Piezo1-regulated lymphangiogenesis mechanism offers a molecular basis for Piezo1-associated lymphatic malformation in humans.