Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta.

Fadi RofoJos BuijsRonny FalkKen HonekLars LannfeltAnna M LiljaNicole G MetzendorfTobias GustavssonDag SehlinLinda SöderbergGreta Hultqvist

Published in: Translational neurodegeneration (2021)

We provide a new antibody design with increased valency to promote binding avidity to an enhanced range of sizes of Aβ aggregates. This approach should be general and work for any aggregated protein or repetitive target.

Keyphrases

monoclonal antibody
binding protein
dna binding
high frequency
protein protein
small molecule