CD8 + chimeric antigen receptor T cells manufactured in absence of CD4 + cells exhibit hypofunctional phenotype.

Sang Yun LeeDong Hoon LeeWei SunFrancisco Cervantes-ContrerasRyan S BasomFeinan WuSi LiuRicha RaiHamid R MirzaeiShyril O'SteenDamian J GreenMazyar ShadmanBrian G Till

Published in: Journal for immunotherapy of cancer (2023)

CAR T cell function, with implications for clinical cell manufacturing.

Keyphrases

induced apoptosis
single cell
cell cycle arrest
stem cells
oxidative stress
signaling pathway
cell proliferation