Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy.

Jingxin LiuTian ZhangJianzhong ZhuShuangchen RuanRongsong LiBing GuoLi-Gen Lin

Published in: Chinese medicine (2021)

These results suggest that HK could ameliorate lipotoxicity in hepatocytes by activating SIRT3-AMPK-lipophagy axis, which might be a potential therapeutic agent against NAFLD.

Keyphrases

signaling pathway
skeletal muscle
liver injury
oxidative stress
ischemia reperfusion injury
protein kinase
drug induced
high glucose
endothelial cells