Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Auyon J GhoshBrian D HobbsJeong H YunAabida SaferaliMatthew MollZhonghui XuRobert P ChaseJarrett MorrowJohn ZinitiFrank SciurbaLucas BarwickAndrew H LimperKevin FlahertyGerard CrinerKevin K BrownRobert WiseFernando J MartinezDaniel McGoldrickMichael H ChoDawn L DeMeoEdwin K SilvermanPeter J Castaldinull nullCraig P Hersh

Published in: Respiratory research (2022)

We identified a divergent gene expression signature between COPD and IPF, with increased expression in COPD and decreased in IPF. This signature is associated with worse lung function in both COPD and IPF.

Keyphrases

idiopathic pulmonary fibrosis
lung function
chronic obstructive pulmonary disease
gene expression
cystic fibrosis
air pollution
interstitial lung disease
dna methylation
rheumatoid arthritis
binding protein