Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse.

Louis-Hippolyte Minvielle MonclaMewen BriendMame Sokhna SyllaSamuel MathieuAnne RufiangeYohan Bosse Patrick Mathieu

Published in: Communications medicine (2024)

Hence, integrative analysis identifies networks of candidate molecules and cells involved in immune control and remodeling of the extracellular matrix, which drive the risk of MVP.

Keyphrases

extracellular matrix
mitral valve
induced apoptosis
cell cycle arrest
genome wide
left atrial
heart failure
left ventricular
endoplasmic reticulum stress
signaling pathway
gene expression
oxidative stress
cell death
cell proliferation