Dynamic proteomic analysis of Aedes aegypti Aag-2 cells infected with Mayaro virus.

Anna Fernanda VasconcellosSamuel Coelho MandacaruAthos Silva de OliveiraWagner FontesReynaldo Magalhães MeloMarcelo Valle de SousaRenato Oliveira ResendeSébastien Olivier Charneau

Published in: Parasites & vectors (2020)

To our knowledge, this first proteomic time-course analysis of MAYV-infected mosquito cells sheds light on the molecular basis of the viral infection process and host cell response during the first 48 hpi. Our data highlight several mosquito proteins modulated by the virus, revealing that MAYV manipulates mosquito cell metabolism for its propagation.

Keyphrases

aedes aegypti
dengue virus
zika virus
induced apoptosis
cell cycle arrest
single cell
cell therapy
healthcare
cell death
signaling pathway
oxidative stress
big data