Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant pleural mesothelioma by 2-tier nuclear grade.
Yu Zhi ZhangCecilia BrambillaPhilip L MolyneauxAlexandra RiceJan L RobertusSimon JordanEric LimLoic Lang-LazdunskiSofina BegumMichael DusmetVladimir AnikinEmma BeddowJonathan FinchNizar AsadiSanjay PopatJohn L QuesneAliya N HusainWilliam O C M CooksonMiriam F MoffattAndrew G NicholsonPublished in: Histopathology (2020)
Our findings support the incorporation of E-MPM with pleomorphic features in the epithelioid subtype as a highly aggressive variant distinct from 2-tier nuclear grade. E-MPM demonstrates extensive heterogeneity in growth pattern but its evaluation does not offer additional prognostic utility to 2-tier nuclear grade.
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