Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics.
Young In ChoiEun-Sook ChoiKwan Ho MunSe Guen LeeSung Jun LeeSang Won JeongSeung Woo LeeHyun-Chul KimPublished in: Polymers (2019)
Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies.
Keyphrases
- drug delivery
- cancer therapy
- reactive oxygen species
- drug release
- cell death
- dna damage
- gene expression
- nitric oxide
- hydrogen peroxide
- liquid chromatography
- papillary thyroid
- young adults
- human immunodeficiency virus
- high resolution
- ionic liquid
- simultaneous determination
- hepatitis c virus
- transcription factor
- solid phase extraction