Wide variation in tissue, systemic, and drain fluid exposure after oxaliplatin-based HIPEC: results of the GUTOX study.
Loek A W de JongFortuné M K ElekonawoMarie LambertJan Marie de GooyerHenk M W VerheulDavid M BurgerJohannes H W de WiltEtienne ChatelutRob Ter HeinePhilip R de ReuverAndre J A BremersNielka P van ErpPublished in: Cancer chemotherapy and pharmacology (2020)
In this exploratory study, no effect was found for postprocedural flushing on platinum concentrations in peritoneal tissue, blood, or drain fluid. BSA-based HIPEC procedure leads to large interpatient variability in platinum exposure in all compartments. The study was registered at ClinicalTrials.gov on 7 December 2017 under registration number NCT03364907.
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