Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System.

Dipak KathayatLinto AntonyLoic Deblais Yosra A HelmyJoy ScariaGireesh Rajashekara

Published in: Infection and drug resistance (2020)

Our study identified two SMs (SM2 and SM3) that potentiated the colistin activity and attenuated the development of colistin resistance in APEC. These SMs can be developed as anti-evolution drugs that can slow down colistin resistance development.

Keyphrases

escherichia coli
klebsiella pneumoniae
acinetobacter baumannii
pseudomonas aeruginosa
small molecule
multidrug resistant
gram negative
drug resistant
cystic fibrosis
staphylococcus aureus
drug induced