Proteomic profiling identifies novel proteins for genetic risk of severe COVID-19: the Atherosclerosis Risk in Communities Study.

Brian T SteffenJames S PankowPamela L LutseyRyan T DemmerJeffrey R MisialekWeihua GuanLogan T CowanJosef CoreshFaye L NorbyWeihong Tang

Published in: Human molecular genetics (2022)

Novel proteomics signatures and pathways for COVID-19-related risk variants TYK2 and ABO were identified. A subset of these proteins predicted greater risk of incident hospitalized pneumonia and respiratory infections. Further studies to examine these proteins in COVID-19 patients are warranted.

Keyphrases

sars cov
coronavirus disease
genome wide
cardiovascular disease
copy number
label free
respiratory syndrome coronavirus
early onset
type diabetes
dna methylation