Dehydroevodiamine targeting IKKβ to alleviate acute gastric injury via inhibiting the p65/NLRP3 axis.
Qichao HuYuan ChenWenwen ZhangYubing LiXinyu DengLisheng ChenZongyuan ZhouXiao MaJinhao ZengYanling ZhaoPublished in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)
DHE attenuated IDO-induced gastric injury by inhibiting the IKKβ-p65/NLRP3 signaling pathway. Notably, DHE is a novel ATP-competitive IKKβ inhibitor that prevents phosphorylation by targeting GLU-149, GLU-49, and ASP-103 in the ATP-binding pocket. This study reveals new targets of action for DHE, providing a new molecular basis for using DHE in treating inflammation-related diseases.
Keyphrases
- signaling pathway
- drug induced
- pi k akt
- liver failure
- oxidative stress
- high glucose
- diabetic rats
- induced apoptosis
- nlrp inflammasome
- respiratory failure
- cancer therapy
- intensive care unit
- cell proliferation
- endothelial cells
- endoplasmic reticulum stress
- transcription factor
- drug delivery
- extracorporeal membrane oxygenation
- dna binding
- mechanical ventilation