MUS81 cleaves TOP1-derived lesions and other DNA-protein cross-links.

Victoria MariniFedor NikulenkovPounami SamadderSissel JuulBirgitta R KnudsenLumír Krejčí

Published in: BMC biology (2023)

Our data indicate that MUS81 and TDP1 play independent roles in the repair of CPT-induced lesions, thus representing new therapeutic targets for cancer cell sensitisation in combination with TOP1 inhibitors.

Keyphrases

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circulating tumor
diabetic rats
big data
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machine learning
amino acid
endothelial cells
artificial intelligence