Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues.
Carlos Enrique Balcazar LopezJuliane AlbrechtVölundur HafstaðCornelia Börjesson FreitagJohan Vallon-ChristerssonCristian BellodiHelena PerssonPublished in: Cancer medicine (2023)
Future work should investigate the effects of alternative isoforms on patient survival and therapy response. An accurate annotation of ER isoforms will aid in interpretation of clinical data and inform functional studies to improve our understanding of the ER in health and disease.
Keyphrases
- estrogen receptor
- endoplasmic reticulum
- public health
- healthcare
- breast cancer cells
- gene expression
- case report
- mental health
- high resolution
- electronic health record
- health information
- stem cells
- big data
- rna seq
- machine learning
- risk assessment
- free survival
- single cell
- social media
- climate change
- mesenchymal stem cells
- human health
- replacement therapy