Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury.
Jesus M Sierra-ParragaAna MerinoMarco EijkenHenri LeuveninkRutger PloegBjarne K MøllerBente JespersenCarla C BaanMartin J HoogduijnPublished in: Stem cell research & therapy (2020)
These results show that MSC have regenerative effects on injured HUVEC via a mechanism which requires both physical and paracrine interaction. The identification of specific effector molecules involved in MSC-HUVEC interaction will allow targeted modification of MSC to apply and enhance the therapeutic effects of MSC in IRI.