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Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury.

Jesus M Sierra-ParragaAna MerinoMarco EijkenHenri LeuveninkRutger PloegBjarne K MøllerBente JespersenCarla C BaanMartin J Hoogduijn
Published in: Stem cell research & therapy (2020)
These results show that MSC have regenerative effects on injured HUVEC via a mechanism which requires both physical and paracrine interaction. The identification of specific effector molecules involved in MSC-HUVEC interaction will allow targeted modification of MSC to apply and enhance the therapeutic effects of MSC in IRI.
Keyphrases
  • endothelial cells
  • stem cells
  • mesenchymal stem cells
  • physical activity
  • bone marrow
  • oxidative stress
  • mental health
  • regulatory t cells
  • cancer therapy
  • immune response
  • high glucose
  • vascular endothelial growth factor