Bioinformatics analysis to reveal the potential comorbidity mechanism in psoriasis and nonalcoholic steatohepatitis.

Ningyi Xian Ruimin BaiJiaqi GuoRuiting LuoHao LeiBingqing WangYan Zheng

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2023)

CHL1 and MBNL2 may participate in the process of psoriasis and NASH via regulating hsa-miR-1305, and together with eight hub genes may be potential therapeutic targets for future treatment for the co-occurrence of these two diseases. This comprehensive bioinformatic analysis provides new insights on molecular pathogenesis and identification of potential therapeutic targets for the co-occurrence of them.

Keyphrases

bioinformatics analysis
genome wide
cell proliferation
human health
long non coding rna
risk assessment
gene expression
dna methylation
single cell
transcription factor
single molecule
atopic dermatitis
smoking cessation
genome wide identification