The prognostic significance of HPV, p16, and p53 protein expression in vaginal cancer: A systematic review.
Christina Louise RasmussenHanna K BertoliFreja L SandAlexander K KjaerLouise T ThomsenSusanne K KjaerPublished in: Acta obstetricia et gynecologica Scandinavica (2021)
This systematic review suggests that women with HPV- and p16-positive vaginal cancer have an improved prognosis compared with those with HPV- or p16-negative vaginal cancer. Results for p53 were varied, and no conclusion could be reached. Only 12 studies could be included in the review, of which most were based on small populations. Hence, further and larger studies on the prognostic impact of HPV, p16, and p53 in vaginal cancer are warranted.