Early Rhythm-Control Therapy in Patients with Atrial Fibrillation.
Paulus F KirchhofA John CammAndreas GoetteAxel BrandesLars EckardtArif ElvanThomas FetschIsabelle C van GelderDoreen HaaseLaurent M HaegeliFrank HamannHein HeidbüchelGerhard HindricksJosef KautznerKarl-Heinz KuckLluis MontG Andre NgJerzy RekoszNorbert SchoenUlrich SchottenAnna SulingJens TaggeselleSakis ThemistoclakisEik VettorazziPanos VardasKarl WegscheiderStephan WillemsHarry J G M CrijnsGünter Breithardtnull nullPublished in: The New England journal of medicine (2020)
Early rhythm-control therapy was associated with a lower risk of adverse cardiovascular outcomes than usual care among patients with early atrial fibrillation and cardiovascular conditions. (Funded by the German Ministry of Education and Research and others; EAST-AFNET 4 ISRCTN number, ISRCTN04708680; ClinicalTrials.gov number, NCT01288352; EudraCT number, 2010-021258-20.).