Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression.

Chiara C BortolasciSrisaiyini KidnapillaiBriana SpoldingTrang T T TruongTimothy ConnorCourtney SwintonBruna PanizzuttiZoe S J LiuAndrew SanigorskiOlivia M DeanTamsyn CrowleyMark RichardsonKiymet BozaogluKaterina VlahosStephanie CowderyBrad WatmuffStephan F SteynDe Wet WolmaransBarend J EngelbrechtChristina PerryKatherine DrummondTerence Y Pang Stéphane JamainLaura GraySean McGeeBrian H HarveyJee Hyun KimMarion LeboyerMichael BerkKen R Walder

Published in: Bipolar disorders (2023)

Collectively our data support the repurposing of trimetazidine for the treatment of bipolar depression.

Keyphrases

gene expression
depressive symptoms
bipolar disorder
sleep quality
dna methylation
big data
combination therapy
artificial intelligence