Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia.

Isabella PototschnigUrsula FeilerClemens DiwokyPaul W VeselyThomas RauchenwaldMargret PaarLatifa BakiriLaura PajedPeter HoferKarl KashoferNyamdelger SukhbaatarGabriele SchoiswohlThomas WeichhartGerald HoeflerChristoph BockMartin PichlerErwin F WagnerRudolf ZechnerMartina Schweiger

Published in: Journal of cachexia, sarcopenia and muscle (2022)

In this study, we present CHX207 fibrosarcoma cells as a novel tool to investigate the mediators and metabolic consequences of CAC in C57BL/6 mice in comparison to non-cachectic MCA207-tumour-bearing mice. IL-6 represents an essential trigger for CAC development in CHX207-tumour-bearing mice.

Keyphrases

high fat diet induced
adipose tissue
induced apoptosis
insulin resistance
skeletal muscle
wild type
metabolic syndrome
oxidative stress
signaling pathway