Effect of active infection on cytochrome P450-mediated metabolism of cyclosporine in renal transplant patients.
S K HegazyA G AdamNoha Alaa HamdyN M KhalafallahPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2015)
CyA trough and SCR levels increased during bacterial and fungal infections and returned to pre-infection levels once the infection was resolved. The data generated stress the importance of monitoring CyA levels during episodes of infection. Our recommendations concerning CyA dose adjustment differ according to severity and duration of infection.