Substantial Reduction in Adjuvant Chemotherapy With the Use of the 21-Gene Test to Manage Early Breast Cancer in a Public Hospital in Brazil.
André MattarGuilherme R FonsecaMurilo B A RomãoJorge Y ShidaVilmar Marques de OliveiraMaria C S BastosFabio BagnoliJose F RinaldiMonica M Á StiepcichMaria A L G da SilvaDebbie M JakubowskiCalvin ChaoSergio C OliveiraLuiz Henrique GebrimPublished in: JCO global oncology (2021)
The change in clinical practice at these public hospitals was greater than expected: 66% of initial treatment recommendations were changed to omit CT with 21-gene test results. Clinicopathologic features did not correlate well with 21-gene test results and did not adequately identify those most likely to benefit from CT.
Keyphrases
- healthcare
- clinical practice
- copy number
- genome wide
- early breast cancer
- genome wide identification
- image quality
- mental health
- contrast enhanced
- dual energy
- dna methylation
- positron emission tomography
- magnetic resonance imaging
- emergency department
- adverse drug
- gene expression
- transcription factor
- magnetic resonance
- electronic health record