Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis.

Sangni QianShujuan LinXin XuHao BaiAibuta YeerkenXiaojiang YingZhenjun LiXinglin FeiJinhua YangMengling TangJianbing WangMingjuan JinKun Chen

Published in: Clinical epigenetics (2022)

The findings reveal that MEF2C-AS1 hypermethylation might be an early driven event during colorectal carcinogenesis. It might serve as a promising prognostic biomarker for CRC survival. Our study also indicates the potential tumor-suppressing role of MEF2C-AS1 in CRC.

Keyphrases

signaling pathway
genome wide
single cell
long noncoding rna
climate change