AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330.

Mingming ZhaoNing CaoHuijun GuJiachao XuWenli XuDi Zhang Tong-You Wade WeiKang WangRuiping GuoHongtu CuiXiaofeng Wang Xin Guo Zhiyuan LiKangmin HeZijian Li Youyi ZhangJohn Y-J ShyyErdan Dong Han Xiao

Published in: Circulation research (2024)

AMPK phosphorylation of β-arrestin-1 Ser330 potentiated PDE4 expression and activity, thereby inhibiting β-AR/cAMP/PKA activation. Subsequently, β-arrestin-1 Ser330 phosphorylation blocks β-AR-induced cardiac inflammasome activation and remodeling.

Keyphrases

protein kinase
high glucose
diabetic rats
skeletal muscle
left ventricular
binding protein
drug induced
signaling pathway
heart failure