Puerarin Alleviates Oxidized Oil-Induced Oxidative Injury and Inflammation via Inhibition of the Nrf2/Keap1 and HMGB1/TLR4/MAPK Signaling Pathways: An Investigation in a Chicken Model.

Daiwen ChenXuan ShiYingmei YuLei YangJingxin OuYangYinhao BianYichun LiuGuan-Hong Li

Published in: Molecular nutrition & food research (2023)

This study demonstrates puerarin may be a potential nutrient supplement in the treatment of oxidized oil-induced damage, and the Nrf2/Keap1 and HMGB1/TLR4/MAPK signaling pathways might be its important target.

Keyphrases

oxidative stress
signaling pathway
diabetic rats
pi k akt
high glucose
toll like receptor
inflammatory response
induced apoptosis
drug induced
low density lipoprotein
cell proliferation
mouse model
small molecule
replacement therapy