Ultrasound-Enhanced Self-Exciting Photodynamic Therapy Based on Hypocrellin B.
Ying DingWeimin LiuJiasheng WuXiuli ZhengJiechao GeHaohui RenWenjun ZhangChun-Sing LeePengfei WangPublished in: Chemistry, an Asian journal (2021)
Peroxalate CL as an energy source to excite photosensitizers has attracted tremendous attention in photodynamic therapy (PDT). In this work, peroxyoxalate CPPO and hypocrellin B (HB)-based nanoparticles (CBNPs) for ultrasound (US)-enhanced self-exciting PDT were designed and prepared. CBNPs showed an excellent therapeutic effect against cancer cells with the assistance of US. This US-enhanced-chemiluminescence system avoids the dependence on external light and provides an example for inspiring more effective and precise strategies for cancer treatment.