Detecting mouse squamous cell carcinoma from submicron full-field optical coherence tomography images by deep learning.
Chi-Jui HoManuel Calderon-DelgadoChin-Cheng ChanMing-Yi LinJeng-Wei TjiuSheng-Lung HuangHomer H ChenPublished in: Journal of biophotonics (2020)
The standard medical practice for cancer diagnosis requires histopathology, which is an invasive and time-consuming procedure. Optical coherence tomography (OCT) is an alternative that is relatively fast, noninvasive, and able to capture three-dimensional structures of epithelial tissue. Unlike most previous OCT systems, which cannot capture crucial cellular-level information for squamous cell carcinoma (SCC) diagnosis, the full-field OCT (FF-OCT) technology used in this paper is able to produce images at sub-micron resolution and thereby facilitates the development of a deep learning algorithm for SCC detection. Experimental results show that the SCC detection algorithm can achieve a classification accuracy of 80% for mouse skin. Using the sub-micron FF-OCT imaging system, the proposed SCC detection algorithm has the potential for in-vivo applications.
Keyphrases
- optical coherence tomography
- deep learning
- squamous cell carcinoma
- diabetic retinopathy
- machine learning
- convolutional neural network
- artificial intelligence
- optic nerve
- loop mediated isothermal amplification
- real time pcr
- label free
- primary care
- lymph node metastasis
- papillary thyroid
- social media
- radiation therapy
- soft tissue
- fluorescence imaging
- mass spectrometry
- wound healing