Removal of H2Aub1 by ubiquitin-specific proteases 12 and 13 is required for stable Polycomb-mediated gene repression in Arabidopsis.

Lejon E M KralemannShujing LiuMinerva S Trejo-ArellanoRafael Muñoz-VianaClaudia KöhlerLars Hennig

Published in: Genome biology (2020)

Our data allow us to propose a model in which deposition of H2Aub1 permits genes to switch between repression and activation by H3K27me3 deposition and removal. Removal of H2Aub1 by UBP12/13 is required to achieve stable PRC2-mediated repression.

Keyphrases

genome wide
transcription factor
genome wide identification
electronic health record
copy number
dna methylation
machine learning
gene expression
deep learning
data analysis