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Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer.

Xu CaoBolei LiJing ChenJessica DangSiqi ChenEmine Gulsen GunesBo XuLei TianSabina MuendMustafa RaoofChristiane QuerfeldJianhua YuSteven T RosenYingyu WangMingye Feng
Published in: Journal for immunotherapy of cancer (2021)
The combination of CD47 blockade and macrophage activation by cabazitaxel synergizes to vastly enhance the elimination of TNBC cells. Our results show that targeting macrophages is a promising and effective strategy for TNBC treatment.
Keyphrases
  • induced apoptosis
  • cancer therapy
  • cell cycle arrest
  • nk cells
  • adipose tissue
  • drug delivery
  • signaling pathway
  • endoplasmic reticulum stress
  • cell proliferation
  • replacement therapy