Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma.

Yifei WangQingxiang LiLe XuJunpeng ChenYinfei PuLin WangHongfang SunYuxing GuoChuanbin Guo

Published in: Oral diseases (2020)

CD10-positive cells are implicated in developing cisplatin resistance of OSCC, which could be related to its cancer stem cell characteristics regulated by the Hedgehog pathway.

Keyphrases

induced apoptosis
cancer stem cells
cell cycle arrest
stem cells
epithelial mesenchymal transition
cell death
oxidative stress
signaling pathway
cell proliferation
pi k akt
lymph node metastasis