Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress.

Xuelin ZhouChing Mei CheungJia-Ming YangPenelope M Y OrWayne Y W LeeJohn H K Yeung

Published in: The Journal of pharmacy and pharmacology (2015)

DSE protected hepatocytes against APAP-induced injury via maintenance of mitochondrial metabolic activity, CYP2E1 inhibition, reduction of total glutathione depletion and preservation of redox status. Danshensu and Sal B were mainly responsible for this protection.

Keyphrases

oxidative stress
diabetic rats
high glucose
dna damage
ischemia reperfusion injury
induced apoptosis
endoplasmic reticulum stress