MSC-extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

Hajer A Al SaihatiArigue A DessoukyRabab F SalimIslam ElgoharyMohamed El-SherbinyFares E M AliMahmoud M A MoustafaDalia ShaheenNicholas Robert ForsythOmnia A M BadrNesrine Ebrahim

Published in: Stem cell research & therapy (2024)

We demonstrated that MSCs-EVs are a potential therapeutic option for treating COVID-19 by preventing viral entry into host cells.

Keyphrases

sars cov
coronavirus disease
induced apoptosis
respiratory syndrome coronavirus
cell cycle arrest
mesenchymal stem cells
single cell
cell therapy
molecular docking
stem cells
cell death
signaling pathway
endoplasmic reticulum stress
oxidative stress
umbilical cord