Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway.
Luhui QinXiaolin ZhangXing ZhouXingchun WuXiang HuangMing ChenYani WuShunyu LuHongliang ZhangXiaohui XuXiaojie WeiShijun ZhangRenbin HuangPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
BACR has potential benefits for the treatment of diabetes by ameliorating metabolic functions and attenuating the inflammatory response via inhibition of the activation of theTLR4/NF-κB pathway.
Keyphrases
- signaling pathway
- inflammatory response
- lps induced
- pi k akt
- diabetic rats
- epithelial mesenchymal transition
- induced apoptosis
- toll like receptor
- oxidative stress
- lipopolysaccharide induced
- nuclear factor
- type diabetes
- high fat diet
- cardiovascular disease
- high glucose
- immune response
- glycemic control
- cell proliferation
- adipose tissue
- insulin resistance
- endothelial cells
- replacement therapy
- endoplasmic reticulum stress