Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden.

Maria C White Jason P Wong Blossom A Damania

Published in: Cancer research communications (2024)

The mitotic kinase, NEK2, is important for the survival of KSHV-positive PEL. NEK2 inhibition resulted in PEL apoptosis and reduced tumor burden in a mouse model. NEK2 inhibition also reduced drug resistance.

Keyphrases

mouse model
oxidative stress
cell death
endoplasmic reticulum stress
risk factors
diffuse large b cell lymphoma
cell cycle
protein kinase