Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria.

Andrew S DavisonBrendan P NormanHazel SutherlandAnna M MilanJames A GallagherJonathan C JarvisLakshminarayan R Ranganath

Published in: Metabolites (2022)

Evaluation of the CSF metabolome of a murine model of AKU revealed a significant increase in the abundance of a limited number of metabolites following treatment with nitisinone. Further work is required to understand the significance of these findings and the mechanisms by which the altered metabolite abundances occur.

Keyphrases

cerebrospinal fluid
ms ms
single cell
antibiotic resistance genes
combination therapy
replacement therapy