How to Preserve Steatotic Liver Grafts for Transplantation.
Damiano PatronoNicola De StefanoElena VissioAna Lavinia ApostuNicoletta PetronioGiovanni VitelliGiorgia CatalanoGiorgia RizzaSilvia CatalanoFabio ColliLuigi ChiusaRenato RomagnoliPublished in: Journal of clinical medicine (2023)
Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has been associated with inferior patient and graft survival, particularly in the case of moderate or severe macrovesicular steatosis. In recent years, the increasing incidence of obesity and fatty liver disease in the population has led to a higher proportion of steatotic liver grafts being used for transplantation, making the optimization of their preservation an urgent necessity. This review discusses the mechanisms behind the increased susceptibility of fatty livers to ischemia-reperfusion injury and provides an overview of the available strategies to improve their utilization for transplantation, with a focus on preclinical and clinical evidence supporting donor interventions, novel preservation solutions, and machine perfusion techniques.
Keyphrases
- insulin resistance
- cell therapy
- ischemia reperfusion injury
- high fat diet induced
- high fat diet
- metabolic syndrome
- oxidative stress
- type diabetes
- risk factors
- physical activity
- early onset
- weight loss
- patients undergoing
- case report
- high intensity
- stem cells
- skeletal muscle
- machine learning
- weight gain
- deep learning
- computed tomography
- bone marrow
- contrast enhanced
- kidney transplantation
- drug induced