Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy.
Hironari KawaiYosuke OsawaMichitaka MatsudaTomoyuki TsunodaKeisuke YanagidaDaisuke HishikawaMiku OkawaraYuzuru SakamotoTomonari ShimagakiYuriko TsutsuiYuichi YoshidaShiori YoshikawaKana HashiHiroyoshi DoiTaizo MoriTaiji YamazoeSachiyo YoshioMasaya SugiyamaDaisuke OkuzakiHaruki KomatsuAyano InuiMiwa Tamura-NakanoChinatsu OyamaHideo ShindouHironori KusanoMasayoshi KageToru IkegamiKatsuhiko YanagaTatsuya KantoPublished in: Hepatology (Baltimore, Md.) (2021)
In conclusion, chronic liver congestion promotes HCC development and liver fibrosis by S1P production from LPS-induced capillarized LSECs. Careful treatment of both RHF and liver cancer might be necessary for RHF patients with primary or metastatic liver cancer.