Functional and anatomical brain connectivity in psoriasis patients and healthy controls: a pilot brain imaging study after exposure to mentally induced itch.
P NajafiD Ben SalemJ-L CarréLaurent MiséryO DuforPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
Our results indicate that there could exist a network which is more interconnected in psoriasis patients. Among two building blocks of this network, the subnetwork encoding the perception and control of itch sensation is more affected than the subnetwork representing mentalizing and empathy. With an approach consisting of measuring microstructural changes at a local level in the brain, we also contradict the findings obtained with global measures which stated that chronic psoriasis cannot alter the anatomy of the brain. This confirms that itchy pathophysiological conditions have similar effects on functional and structural connectivity as those observed in chronic pain.
Keyphrases
- white matter
- resting state
- end stage renal disease
- functional connectivity
- chronic pain
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- cerebral ischemia
- multiple sclerosis
- endothelial cells
- high glucose
- patient reported outcomes
- study protocol
- mass spectrometry
- drug induced
- patient reported