Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides.

Chang LiuKun ChenFei ZhaoLingling XuanYuting WangChungui XuZhiyuan WuDongmei WangChunfeng Qu

Published in: BMC medicine (2022)

HBV PreS mutations which altered amino acid properties of envelope proteins inhibited HBsAg secretion. Hepatocyte infection with PreS variants generated abnormal ceramides which with HBV proteins coactivated NLRP3 inflammasome in liver macrophages to promote autochthonous HCC development.

Keyphrases

hepatitis b virus
high fat diet
nlrp inflammasome
liver failure
insulin resistance
copy number
amino acid
adipose tissue
gene expression
dna methylation