The use of mesenchymal stem cells in animal models for gastrointestinal anastomotic leak: A systematic review.

Joshua Richard BurkeJack HelliwellJason WongAaron QuynSarah HerrickDavid Jayne

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)

Mesenchymal stem cell delivery to an animal anastomosis is safe and feasible. Use may confer benefit but findings are currently limited to surrogate histological outcomes. There is consistency in outcome measures reported but variance in how this is assessed. Poor compliance to ARRIVE but good compliance to current international consensus in leak models of the colon was observed.

Keyphrases

mesenchymal stem cells
umbilical cord
bone marrow
rectal cancer
cell therapy
clinical practice
stem cells
adipose tissue
skeletal muscle