Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis.
Savvina PrapiadouLuka ŽivkovićBarbara ThorandMarc J GeorgeSander W van der LaanRainer MalikChristian HerderWolfgang KoenigThor UelandOla KlevelandPål AukrustLars GullestadJürgen BernhagenGerard PasterkampAnnette PetersAroon D HingoraniJonathan RosandMartin DichgansChristopher D AndersonMarios K GeorgakisPublished in: Circulation (2023)
Integrating multiomics data, we found a proteomic signature of IL-6 signaling activation and mediators of its effects on cardiovascular disease. Our analyses suggest the interferon-γ-inducible chemokine CXCL10 to be a potentially causal mediator for atherosclerosis in 3 vascular compartments and, as such, could serve as a promising drug target for atheroprotection.