Login / Signup

Fission-independent compartmentalization of mitochondria during budding yeast cell division.

Saori R YoshiiYves Barral
Published in: The Journal of cell biology (2024)
Lateral diffusion barriers compartmentalize membranes to generate polarity or asymmetrically partition membrane-associated macromolecules. Budding yeasts assemble such barriers in the endoplasmic reticulum (ER) and the outer nuclear envelope at the bud neck to retain aging factors in the mother cell and generate naïve and rejuvenated daughter cells. However, little is known about whether other organelles are similarly compartmentalized. Here, we show that the membranes of mitochondria are laterally compartmentalized at the bud neck and near the cell poles. The barriers in the inner mitochondrial membrane are constitutive, whereas those in the outer membrane form in response to stresses. The strength of mitochondrial diffusion barriers is regulated positively by spatial cues from the septin axis and negatively by retrograde (RTG) signaling. These data indicate that mitochondria are compartmentalized in a fission-independent manner. We propose that these diffusion barriers promote mitochondrial polarity and contribute to mitochondrial quality control.
Keyphrases
  • endoplasmic reticulum
  • oxidative stress
  • single cell
  • quality control
  • cell therapy
  • cell death
  • induced apoptosis
  • stem cells
  • deep learning
  • electronic health record
  • bone marrow
  • artificial intelligence