FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter.

Zhuoying LinWenjie HuangQin HeDongxiao LiZhihui WangYangyang FengDanfei LiuTongyue ZhangYijun WangMeng XieXiaoyu JiMengyu SunDean TianLimin Xia

Published in: Journal of experimental & clinical cancer research : CR (2021)

In a word, we clarify that the positive feedback loop of ROS-FOXC1-cysteine metabolism-ROS is important for promoting liver cancer proliferation and metastasis, and this pathway may provide a prospective clinical treatment approach for HCC.

Keyphrases

dna methylation
signaling pathway
cell death
dna damage
reactive oxygen species
transcription factor
circulating tumor
gene expression
single molecule
cell free
combination therapy
circulating tumor cells